Ziraoui, Nour-Eddine and Rahman, Hafiz and Hidayah, Nurul (2026) Calcium, Vitamin D, and Prebiotic Components: Evidence on Bone Mineralization and Bone Mineral Density. Journal of Science in Medicine and Life, 4 (8). ISSN 2992-9202

Text JSML_Nour-Eddine+Ziraoui_Calcium,+Vitamin+D,+and+Prebiotic.pdf Download (487kB)

Abstract

Background: Bone mineral density (BMD) reflects the long-term balance between mineral intake, bone turnover, age, hormonal status, vitamin D status, and habitual nutrient intake. The NVTIA® formulation examined in this article contains calcium citrate malate, calcium L-lactate, casein phosphopeptide (CPP), inulin, resistant dextrin, and microencapsulated vitamin D3. Objective: To assess whether the rationale for this formulation is consistent with human evidence on calcium supplementation, bone mineralization, and BMD. Methods: The formulation composition and technical characteristics were considered together with a focused review of human clinical evidence available through 14 August 2026. Randomized trials of calcium salts, calcium with vitamin D, and prebiotic-assisted calcium interventions were considered, together with meta-analytic evidence on bone loss. Results: The clinical response to calcium supplementation was not uniform. Greater effects were generally reported in older adults, women with vitamin D deficiency, women later after menopause, and individuals with lower calcium intake. Controlled studies support calcium citrate and CCM as calcium sources with effects on BMD or bone loss in selected populations. Calcium combined with vitamin D also improved BMD at several skeletal sites in some older populations. In adolescents, inulin-type fructans increased calcium absorption and whole-body mineral accrual. In contrast, the 2026 RENEW trial did not show an additional BMD benefit from adding inulin to a calcium-rich permeate regimen in vitamin-D-supplemented postmenopausal women. A meta-analysis in adults aged 50 years and older found modest preservation of hip and spine BMD with calcium, with or without vitamin D. Conclusion: The available evidence provides a reasonable basis for evaluating the formulation as a bone-health intervention, but the expected response is likely to depend on age, baseline calcium and vitamin D status, and adherence. A clinical study of the finished tablet should therefore define elemental-calcium intake and vitamin D exposure and include standardized measures such as serum 25(OH)D, bone-turnover markers, and site-specific DXA.

Item Type:	Article
Uncontrolled Keywords:	bone mineral density, bone mineralization, calcium citrate malate, calcium, vitamin D, inulin, postmenopause, DXA
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	05 Nov 2026 08:27
Last Modified:	05 Nov 2026 08:27
URI:	http://eprints.umsida.ac.id/id/eprint/17480

Actions (login required)

View Item