Igoundaz, Yassine and Brooks, Preston and Palmer, Derek (2026) Stability-Preserved Lycopene in a Low-Oxygen Lipid Matrix: Oxidative-Stress Biomarkers and Human Nutritional Relevance. American Journal of Bioscience and Clinical Integrity, 3 (9). ISSN 2997-7347

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Abstract

A low-oxygen lycopene lipid complex was characterized for extraction transfer, isomeric integrity, oil-phase quality, and accelerated stability. The three optimized formulations transferred 78.2-82.1% of lycopene from the processed peel material, contained 2.13-2.34% total lycopene, and retained 85.1-86.2% in the all-trans form. After 30 days at 45°C under nitrogen and light protection, total lycopene retention remained 90.8-91.6%; ABTS capacity retained 89.8-90.8% of baseline. Human lycopene studies show endpoint-specific redox responses rather than a uniform antioxidant effect. Purified lycopene has altered DNA-oxidation measures and superoxide dismutase activity in randomized trials, while tomato-food interventions have changed resistance of lipoproteins or lymphocytes to experimental oxidation. The formulation data define a chemically stable starting material for human studies in which circulating lycopene, isomer distribution, and a small prespecified redox-biomarker panel are measured together.

Item Type:	Article
Uncontrolled Keywords:	lycopene, oxidative stress, carotenoids, antioxidant defense, all-trans lycopene, lipid matrix, tomato, NVTIA®
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 08:02
Last Modified:	04 Nov 2026 08:02
URI:	http://eprints.umsida.ac.id/id/eprint/17437

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