Ziraoui, Nour-Eddine and Boateng, Kofi and Ndlovu, Nomsa (2026) IN VITRO GASTROINTESTINAL CALCIUM RELEASE FROM AN ORGANIC CALCIUM–CPP GRANULE MATRIX AND ITS TRANSLATIONAL RELEVANCE TO BIOAVAILABILITY. Journal of Healthcare Science and Management, 1 (4). ISSN 3124-0615

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Abstract

Objective: This study evaluated an NVTIA organic calcium–casein phosphopeptide (CPP) composite tablet built from calcium citrate malate, calcium L-lactate, CPP, inulin, resistant dextrin and microencapsulated vitamin D3. Method: The optimized granule system achieved 84.7% calcium release after 30 min in gastric-phase medium and 61.5% soluble calcium retention after 60 min in intestinal-phase medium. Corresponding values were lower in a CPP/inulin-free comparator (76.2% and 50.8%), a wet-granulated vitamin D3 comparator (78.5% and 52.1%), and a direct-blending comparator (70.4% and 46.7%). Results: Human studies of calcium citrate malate and inulin-type fructans provide clinically relevant context for these physicochemical findings and a useful framework for future direct quantification of absorption with the complete formulation. Novelty: Taken together, the evidence supports a formulation-level strategy in which organic calcium dissolution, CPP-associated maintenance of calcium solubility, and fermentable-fiber effects are considered jointly, with single-ingredient studies serving as complementary mechanistic context.

Item Type:	Article
Uncontrolled Keywords:	calcium citrate malate, calcium L-lactate, casein phosphopeptide, inulin, calcium bioavailability, gastrointestinal release, NVTIA
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 07:53
Last Modified:	04 Nov 2026 07:53
URI:	http://eprints.umsida.ac.id/id/eprint/17429

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