Younis, Noha Abdulsalam (2026) Effect of Pumpkin Seed Oil and Vitamin E on Histological Changes Liver of Rabbite Liver. American Journal of Biomedicine and Pharmacy, 3 (10). ISSN 2997-7177

Text biojournals_AJBP_Effect+of+Pumpkin+Seed+Oil+and+Vitamin+E.pdf Download (948kB)

Abstract

The study evaluated the histological and biochemical effects of pumpkin seed oil (PSO), with or without vitamin E, on the liver of male rabbits. Twelve four-month-old rabbits were allocated to three groups (n = 4) and treated for three weeks. Serum ALT and AST activities and hepatic histology were assessed. PSO alone increased ALT (42.53 ± 0.78 U/L) and AST (46.63 ± 4.50 U/L) compared with controls (34.83 ± 0.60 and 33.90 ± 0.21 U/L, respectively), whereas vitamin E supplementation reduced these activities to 27.70 ± 3.15 and 34.70 ± 0.30 U/L. Histologically, PSO induced alterations in liver appearance and central vein diameter, while vitamin E supplementation was associated with reduced biochemical alterations. These findings suggest that vitamin E may mitigate PSO-associated hepatic changes, potentially through antioxidant activity.

Item Type:	Article
Uncontrolled Keywords:	Pumpkin seed oil, Vitamin E, Rabbit liver, Liver enzymes, Histological
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	29 Oct 2026 15:36
Last Modified:	29 Oct 2026 15:36
URI:	http://eprints.umsida.ac.id/id/eprint/17325

Actions (login required)

View Item