AYKHODJAEVA, Mokhira and ALIMOVA, Kamola and ABDURAUFOV, Abdulla and DAVLETBAEVA, Sadoqat (2026) Characteristics of Renal Anaemia in Patients with Chronic Kidney Disease and Diabetes Mellitus. Central Asian Journal of Medical and Natural Science, 7 (4). ISSN 2660-4159

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Abstract

Aim. To systematize current evidence on the mechanisms, clinical features, and diagnosis of renal anaemia in patients with chronic kidney disease and diabetes mellitus. Material and methods. A narrative review of publications from 2010 to 2026 was performed using the PubMed, Scopus, Web of Science, and eLIBRARY.ru databases. The analysis included studies containing data on the pathogenesis, laboratory parameters, and treatment approaches to anaemia in chronic kidney disease (CKD) and diabetes mellitus. Results. A decline in erythropoietin production is observed once the glomerular filtration rate falls below 60 mL/min/1.73 m² [1]. In patients with diabetes mellitus, anaemia is recorded at earlier stages of CKD-at a glomerular filtration rate of 60–90 mL/min/1.73 m² [2]. A haemoglobin concentration below 120 g/L is detected in 20–40% of patients with diabetic nephropathy [3]. Elevated hepcidin levels restrict iron mobilization and reduce the efficiency of erythropoiesis [4]. Inflammatory markers, including C-reactive protein, correlate with a decline in haemoglobin and with resistance to erythropoietin therapy [5]. Conclusions. Renal anaemia in diabetes mellitus is characterized by an earlier onset and by the coexistence of several pathophysiological mechanisms: erythropoietin deficiency, chronic inflammation, and disturbances of iron metabolism. Diagnosis requires assessment of haemoglobin, ferritin, transferrin, and the level of inflammatory markers. Treatment approaches must take into account the combined nature of the pathogenesis.

Item Type:	Article
Uncontrolled Keywords:	renal anaemia, chronic kidney disease, diabetes mellitus, erythropoietin, hepcidin, iron deficiency
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	27 Jul 2026 14:47
Last Modified:	27 Jul 2026 14:47
URI:	http://eprints.umsida.ac.id/id/eprint/16846

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