Jasim, Oday Jawad and Al-Tmemy, Wisam Basim and Awad, Atheer Fouad (2026) The Prognostic Role of Interleukin-6 in Predicting Mortality among Patients at the Onset of Dialysis. World of Medicine : Journal of Biomedical Sciences, 3 (5). pp. 100-109. ISSN 2960-9356

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Abstract

Chronic kidney disease is a major global health problem and a potentially life-threatening condition, particularly in patients at the onset of dialysis. This study was carried out at Wasit Province / Iraq in cooperation with Al-Fayrowz Hospital and Al-Zahraa Hospital. The aim of this study was to evaluate the serum levels of interleukin-6 (IL-6) and to evaluate the prognostic role of this cytokine in predicting mortality among patients at the onset of dialysis. Samples were collected from multiple sites across Wasit Province. The study included 42 blood samples from Iraqi patients undergoing repeated hemodialysis sessions and 7 healthy subjects as a control group. The study was conducted during the period from 2025–2026. The age range in both groups was 20–60 years and included both males and females. Serum samples were collected from all participants and analyzed for cytokine levels using enzyme-linked immunosorbent assay (ELISA). All required reagents and equipment were readily available in standard blood testing kits. There were statistically significant differences in the mean serum IL-6 levels between dialysis patients and healthy controls. The calculated P-value was less than 0.001 for the investigated variable. However, as a key mediator of inflammation, IL-6 is also involved in immune dysregulation, persistent systemic inflammation, and disease progression in patients undergoing dialysis. Overall, the current findings highlight IL-6 as a crucial prognostic and immunoregulatory cytokine at the onset of dialysis. Immunotherapeutic strategies aimed at modulating the effects of IL-6 in dialysis patients may hold promise in the future, as they should enhance its prognostic utility while mitigating its potential deleterious effects.

Item Type:	Article
Subjects:	A General Works > AI Indexes (General)
Depositing User:	admin eprints
Date Deposited:	05 Jun 2026 13:29
Last Modified:	05 Jun 2026 13:29
URI:	http://eprints.umsida.ac.id/id/eprint/16527

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