The Role of Ferritin in the Body

Amirqulova, Gulhayo Murodullayevna and Xidirova, Nigora Xolmurzayevna (2024) The Role of Ferritin in the Body. International Journal of Integrative and Modern Medicine, 2 (11). pp. 135-139. ISSN 2995-5319

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Abstract

Ferritin, a crucial iron-storage protein, plays a vital role in controlling iron homeostasis, safeguarding cells from iron-induced oxidative damage, and facilitating cellular metabolism. Iron equilibrium is essential for various biological processes, including oxygen transport, DNA synthesis, and electron transfer. Abnormal ferritin levels, whether increased or decreased, are linked to various conditions, including anaemia, neurodegenerative diseases, cardiovascular disease, and cancer, underscoring the necessity for a more profound comprehension of ferritin's regulatory processes. Nonetheless, despite ferritin's essential function, the mechanisms by which it regulates iron availability in various tissues and in reaction to fluctuating iron levels remain little understood.This work utilised biochemical assays, cell culture models, and high-resolution imaging techniques to examine the cellular and molecular roles of ferritin. We evaluated ferritin expression and iron-binding capacity under scenarios of iron surplus and deficit, and investigated its relationships with other proteins associated with iron transport and storage. Our findings indicate that ferritin operates dynamically within a network of iron regulatory proteins, enabling iron buffering and redistribution across cellular compartments to enhance mitochondrial performance and safeguard against oxidative stress.This discovery expands our comprehension of ferritin, revealing it as an active participant in cellular iron transport rather than only a storage molecule. These results may possess therapeutic implications, presenting prospective targets for addressing disorders associated with iron imbalance, and provide a basis for future investigations into ferritin's function in systemic and cellular iron regulation.

Item Type:	Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Postgraduate > Master's of Management
Depositing User:	Journal Editor
Date Deposited:	26 Dec 2024 10:17
Last Modified:	26 Dec 2024 10:17
URI:	http://eprints.umsida.ac.id/id/eprint/15011

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