THE USE OF 2-ACETYL PYRAZINE AS A BASIC NUCLEOPHILE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 5,6-DIHYDROPYRIDINE-2(1H)-YLIDENE)CYANAMIDE RING, THEIR DIAGNOSIS, AND EVALUATION OF THEIR BACTERIAL EFFICACY

Noor Abdel Reda, shalal and Khalid A., Al-Badrany (2024) THE USE OF 2-ACETYL PYRAZINE AS A BASIC NUCLEOPHILE FOR THE PREPARATION OF NEW DERIVATIVES OF THE 5,6-DIHYDROPYRIDINE-2(1H)-YLIDENE)CYANAMIDE RING, THEIR DIAGNOSIS, AND EVALUATION OF THEIR BACTERIAL EFFICACY. European Journal of Modern Medicine and Practice, 4 (5). pp. 508-518. ISSN 2795-921X

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Abstract

Due to the great importance of heterocyclic rings, especially hexacyclic rings, in recent years, due to their great importance in the medical and pharmaceutical field, new derivatives of the ring of permidine, one of the heterocyclic hexacyclic rings prepared from the reaction of Chaluconate derivatives with cyanoguandine, have been prepared in this research, where the compound 2-Acetyl pyrazine was adopted as the primary nucleus in the preparation of gluconates used as intermediate compounds. The reactions took place in a base medium of sodium hydroxide. These compounds were diagnosed using physical properties such as color and melting point and spectral methods, including the infrared spectrum (FT-IR) and the proton-carbon (1H-NMR)(13C-NMR) nuclear magnetic resonance spectrum. The effectiveness of these compounds was measured against different types of gram-negative bacteria, such as (Escherichia coli) and gram-positive bacteria, such as (Staphylococcus aureus) and the use of amoxicillin as a control sample to compare with the results of inhibition of these compounds.

Item Type: Article
Subjects: L Education > L Education (General)
Divisions: Postgraduate > Master's of Islamic Education
Depositing User: Journal Editor
Date Deposited: 24 Oct 2024 05:26
Last Modified: 24 Oct 2024 05:26
URI: http://eprints.umsida.ac.id/id/eprint/14336

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