Antibacterial Activity of Rhizome Extracts of Zingiber zerumbet (L.) Roscoeex Sm. Against Streptococcus pneumoniae

Rohmah, Jamilatur and Rini, Chylen Setiyo (2022) Antibacterial Activity of Rhizome Extracts of Zingiber zerumbet (L.) Roscoeex Sm. Against Streptococcus pneumoniae. Proceedings of the 1st SENARA 2022, 1 (1). pp. 1007-1016. ISSN 2722-0672

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Abstract

Streptococcus pneumoniae is a bacterium that causes infections of the respiratory tract (ARI), in its handling in the community usually use antibiotics. Antibiotics themselves if used continuously lead to resistance. One of the plants that contain secondary metabolites that are thought to be used as antibacterial is the Lempuyang Gajah (Zingiber zerumbet (L.) Roscoe ex Sm.) plant. This study aimed to determine the secondary metabolite content of Lempuyang Gajah rhizome and to determine the antibacterial activity of lempuyang extract on Streptococcus pneumoniae bacteria. The method used in this research is the diffusion method with paper discs to determine the inhibitory power. The lempuyang plants used were obtained from the village of Tegal Bulu Banyuwangi and isolates of S. pneumoniae ATCC 49619 were obtained from the Central Health Laboratory (BBLK) Surabaya. The concentrations of the extracts used were 20, 40, 60, 80, and 100% with a positive control of chloramphenicol. The data obtained was then carried out with One Way Anova statistical test. The results showed that the phytochemical test of the ethanol extract of lempuyang elephant (Zingiber zerumbet (L.) Roscoe ex Sm.) contained alkaloids, flavonoids, saponins, steroids, triterpenoids, phenolics, and tannins. The ethanolic extract of lempuyang elephant (Zingiber zerumbet (L.) Roscoe ex Sm.) can inhibit the growth of the bacteria S. pneumoniae ATCC 49619 known from the inhibition zone formed. The results of the inhibitory test showed that the higher the concentration of the elephant lempuyang extract, the larger the diameter of the inhibitor formed. In lempuyang Gajah, the highest mean inhibition diameter was found at a concentration of 100% at 43.9 ± 3.6 mm. The results of the One Way Anova statistical test showed that there was a significant effect (p<0.05) between the elephant lempuyang extract on the Streptococcus pneumoniae bacteria. This indicates that the ethanolic extract of the lempuyang elephant rhizome has antibacterial activity against Streptococcus pneumoniae bacteria.

Item Type:	Article
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Health Science > School of Health Analyst
Depositing User:	tlm umsida
Date Deposited:	29 Dec 2022 23:26
Last Modified:	29 Dec 2022 23:26
URI:	http://eprints.umsida.ac.id/id/eprint/10879

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