Obeed, Dr. Ameer Najy and Hammadi, Ali. S. and Handool, Kareem Obayes (2026) TARGETED PHOTO-INDUCED THERMAL ANNIHILATION OF DRUG-RESISTANT BACTERIAL PATHOGENS UTILIZING ENGINEERED METALLIC PLASMONIC NANOARCHITECTURES. Journal of Medical Genetics and Clinical Biology, 3 (7). ISSN 3032-1085

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Abstract

Objective: This work assesses the biophysical capability of bio-synthesized silver nanoparticles (AgNPs) and gold nanorods (AuNRs) functionalized with target-specific antibodies to selectively exterminate Staphylococcus aureus and Pseudomonas aeruginosa under near-infrared (NIR) laser stimulation (Sperling & Parak, 2008; Uusitalo et al., 2025). Method: Metallic nanostructures were fabricated through eco-friendly green chemistry procedures and comprehensively characterized via UV-Vis spectrophotometry, transmission electron microscopy (TEM), and atomic force microscopy (AFM) (Alivisatos, 1996; Kelly et al., 2003). Bacterial cultures were subjected to an 808 nm optical laser field across diverse power densities (0.5–2.0 W/cm²), followed by real-time tracking of localized micro-hyperthermia, cell envelope degradation, and bacterial survival kinetics (Indhu et al., 2023; Link & El-Sayed, 1999). Results: Synthesized AuNRs exhibited an intense, localized surface plasmon resonance (LSPR) band centered at 808 nm, achieving a localized temperature elevation (ΔT) of 24.5 °C within a 5-minute irradiation window at 50 µg/mL (Huang et al., 2006). This light-to-heat energy transduction triggered irreversible protein coagulation, lipid membrane oxidation, and an overall 99.8% mortality rate in resistant isolates without incurring cytotoxicity to non-target mammalian cells (Vankayala & Hwang, 2018; Zhou et al., 2022). Novelty: Plasmonic-driven photothermal therapy represents an exceptionally effective, rapid, and biophysically distinct paradigm capable of bypassing conventional bacterial resistance mechanisms.

Item Type:	Article
Uncontrolled Keywords:	Silver Nanoparticles (AgNPs), Gold Nanorods (AuNRs), Photothermal Therapy, Antibacterial Activity, Near-Infrared (NIR) Laser
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	05 Nov 2026 02:11
Last Modified:	05 Nov 2026 02:11
URI:	http://eprints.umsida.ac.id/id/eprint/17472

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