Igoundaz, Yassine and West, Adrian and Robertson, Levi (2026) A Fruit-Derived Vitamin C–Polyphenol Matrix for Collagen Formation and Tissue Integrity: Stability Characteristics and Human Healing Evidence. American Journal of Biology and Natural Sciences, 3 (9). ISSN 2997-7185

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Abstract

The NVTIA® fruit-derived vitamin C-polyphenol powder was evaluated as a stable nutritional input for collagen- and tissue-repair research. The optimized powders contained 16.8-18.4% L-ascorbic acid and 7.9-8.8% corrected total polyphenols, with water activity of 0.23-0.25. After 30 days of accelerated storage, L-ascorbic acid retention was 87.5-89.1%; direct dry mixing, removal of the protective matrix, and a conventional carrier gave lower retention and higher hygroscopicity. Human healing studies are not uniform. A small double-blind trial reported better foot-ulcer healing with 500 mg/day slow-release vitamin C, whereas a pressure-ulcer trial using 500 mg twice daily did not improve wound closure. Multi-nutrient pressure-ulcer studies and collagen-synthesis experiments show that baseline nutrition, wound type, co-interventions, and exposure context materially affect the observed response. The stable fruit-derived matrix is therefore suited to direct studies that pair measured vitamin C exposure with collagen or tissue-integrity endpoints.

Item Type:	Article
Uncontrolled Keywords:	vitamin C, collagen, wound healing, skin integrity, connective tissue, acerola, polyphenols, stability
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 08:05
Last Modified:	04 Nov 2026 08:05
URI:	http://eprints.umsida.ac.id/id/eprint/17439

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