Igoundaz, Yassine and Walsh, Declan and Price, Connor (2026) Fruit-Derived Vitamin C and Polyphenols in Cardiometabolic Nutrition: Formulation Stability, Glycemic Evidence, and Vascular Relevance. International Journal of Applied and Traditional Medicine, 3 (3). ISSN 2997-1128

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Abstract

The NVTIA® fruit-derived vitamin C-polyphenol powder was characterized for composition and storage performance and then compared with human cardiometabolic evidence. The optimized formulations contained 16.8-18.4% L-ascorbic acid and 7.9-8.8% corrected total polyphenols. Thirty-day L-ascorbic acid retention was 87.5-89.1%, with 24-hour hygroscopicity of 5.8-6.3%; direct dry mixing or removal of the protective matrix produced lower retention and substantially greater hygroscopicity. In type 2 diabetes, a randomized crossover trial using 1 g/day ascorbic acid improved postprandial and 24-hour glycemia and reduced blood pressure. Meta-analyses report modest average changes in glycemic control, endothelial function, and blood pressure, but individual trials include both positive and neutral results. Phyllanthus emblica studies add a polyphenol-rich fruit context for endothelial and lipid endpoints. The formulation therefore supplies a stable ascorbate-polyphenol exposure for cardiometabolic studies in which baseline phenotype and biochemical exposure are measured directly.

Item Type:	Article
Uncontrolled Keywords:	vitamin C, polyphenols, glucose metabolism, endothelial function, blood pressure, Phyllanthus emblica, cardiometabolic health, antioxidant
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 08:03
Last Modified:	04 Nov 2026 08:03
URI:	http://eprints.umsida.ac.id/id/eprint/17438

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