Igoundaz, Yassine and Harding, Oscar and Pierce, Samuel (2026) Stability-Preserved Lycopene and Nutritional Photoprotection: Human Evidence for Resistance to UV-Induced Skin Stress. International Journal of Applied and Traditional Medicine, 3 (3). ISSN 2997-1128

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Abstract

Lycopene stability in an oil matrix was examined alongside human studies of nutritional photoprotection. The three optimized formulations contained 2.13-2.34% total lycopene, with 85.1-86.2% in the all-trans form. After 30 days at 45°C, total lycopene retention was 90.8-91.6%. Process comparisons were more variable: removing the oil-phase antioxidant system, extending extraction at high temperature, or using high-temperature enzyme inactivation reduced all-trans integrity and/or storage retention. Human tomato and lycopene studies use a repeated-intake design rather than an acute sunscreen model. Tomato paste providing about 16 mg/day lycopene for 10-12 weeks reduced UV-induced erythema, and randomized work also recorded changes in MMP-1, procollagen-related responses, mitochondrial DNA damage, and UV-responsive inflammatory markers. A 2024 systematic review/meta-analysis of 21 intervention trials reported favorable changes across erythema, minimal erythema dose, MMP-1, ICAM-1, skin thickness, and density. The formulation data define a chemically stable lycopene exposure for direct studies that pair plasma or skin carotenoid status with prespecified UV-response endpoints.

Item Type:	Article
Uncontrolled Keywords:	lycopene, photoprotection, ultraviolet radiation, erythema, skin aging, carotenoids, tomato, NVTIA®
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 07:59
Last Modified:	04 Nov 2026 07:59
URI:	http://eprints.umsida.ac.id/id/eprint/17434

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