Allawi, Muhammed Salih (2024) Level of IgE and Eosinophils in Patients with Asthma. International Journal of Health Systems and Medical Sciences, 3 (5). ISSN 2833-7433

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Abstract

Objective: knowledge the predictive roles of eosinophil and IgE in pathophysiology of asthma patients in Tikrit  city. Methods: The current research was applied  in  Tikrit city between February and April 2024.  city during period (February-April 2024).  We collect 60 blood samples from patients with asthma  which is visiting advisory  unit / tikrit Teaching Hospital  (those patients have been diagnosis already by consultant doctor). Additionally, we collect 30 samples from people without diseases (healthy) and based on them  as a control  group.  Absolute  count of eosinophil was measured by hematology analyzer machine (complete blood count (CBC)). Levels of IgE  were calculated  by Sandwich Enzyme-linked immunosorbent assays (ELISA). Results:  Present outcomes  showed the most participants were lie within  age groups; 41-50 (25%) and 51-60 years (32%) and living in urban area (65%).  Additionally, our study mentioned the most cases were genetic (68%), moderate severity (52%), and have duration time >10 years (47%). Increase  concentrations of  IgE, eosinophil and IgE+Eosinophil indicators in isthmic patients than control individuals  with significant differences (p<0.05). Based on ROC curve, our study  showed the IgE+eosinophil indicator has highest sensitivity, specificity, PPV, and NPV (90%, 95%, 90%, and 90%), followed by IgE (84%, 90%, 88% and 81%) and then eosinophil (80%, 80%, 80%, and 80%) at cut off values (418.00, 98.50, and 291.91) respectively in diagnosis asthma patients with significant differences (p<0.05). Conclusions: Peoples with >40 years are more dangerous for asthma occurrences than younger. Urban area is more risk  for disease than rural due to it has more pollutions. Genetic predisposition play major role in asthma occurrence. Increased levels of IgE and eosinophil in astmatic diseases due to increase inflammation. Finally, IgE+Eosinophil indicator is more better in diagnosis asthma  than IgE and eosinophil due to it has highest sensitivity and specificity.

Item Type:	Article
Uncontrolled Keywords:	Asthma, eosinophilic asthma, allergy, IgE, eosinophil
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	04 Nov 2026 07:55
Last Modified:	04 Nov 2026 07:55
URI:	http://eprints.umsida.ac.id/id/eprint/17431

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