Obeed, Ameer Najy and Khudir, Thara Habeeb and Merza, Zahraa Hamza and Hussein, Howadia Nazzal and Rahman, Dhai Mohammed and Kumait, Ali (2026) STUDY OF KEY IMMUNOLOGICAL AND HEPATIC INDICATORS IN PATIENTS WITH HEPATITIS B VIRUS ATTENDING AND ADMITTED TO MERJAN TEACHING HOSPITAL IN BABYLON PROVINCE. Journal of Medical Genetics and Clinical Biology, 3 (9). ISSN 3032-1085

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Abstract

Objective: This cross-sectional study aimed to evaluate key hepatic cellular markers and systemic inflammatory responses among HBV-infected patients attending outpatient clinics and admitted to inpatient wards at Merjan Teaching Hospital in Babylon Province, Iraq. Method: Serum levels of liver transaminases—alanine aminotransferase (ALT) and aspartate aminotransferase (AST)—were quantitatively measured alongside pro-inflammatory cytokines, specifically Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α), using Enzyme-Linked Immunosorbent Assay (ELISA) techniques, and compared against healthy controls. Results: Statistically significant elevations (p ≤ 0.01 for liver enzymes; p ≤ 0.001 for cytokines) were observed in HBV patients compared to the control group. Novelty: These findings demonstrate that continuous immune-mediated hepatocyte destruction and cytokine dysregulation drive the pathogenesis of HBV, underlining the clinical relevance of incorporating cytokine profiling alongside standard liver function tests for improved diagnostic and prognostic monitoring.

Item Type:	Article
Uncontrolled Keywords:	Hepatitis B Virus, ALT, AST, IL-6, TNF-α
Subjects:	H Social Sciences
Depositing User:	admin eprints
Date Deposited:	28 Oct 2026 13:20
Last Modified:	28 Oct 2026 13:20
URI:	http://eprints.umsida.ac.id/id/eprint/17285

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