BROADENING CANCER DETECTION WITH POPULATION-BASED GENETIC TESTING FOR WOMEN

Kamalova, D.D and Norxujaeva, Ch.B (2024) BROADENING CANCER DETECTION WITH POPULATION-BASED GENETIC TESTING FOR WOMEN. European Journal of Modern Medicine and Practice, 4 (7). pp. 467-470. ISSN 2795-921X

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Abstract

The review article explores the potential of population-based genetic testing (PBGT) for the precision prevention of women's cancers, focusing on breast, ovarian, and endometrial cancers. Current genetic testing strategies, primarily based on family history models, have significant limitations, leading to underutilization and missed opportunities for early cancer detection and prevention. PBGT offers a novel approach by enabling broader identification of cancer-susceptibility gene (CSG) carriers, facilitating targeted screening, and preventive interventions. The review addresses the psychological, economic, and ethical implications of PBGT, highlighting its feasibility, cost-effectiveness, and impact on cancer incidence reduction. Research findings suggest high acceptability and satisfaction with PBGT, especially in founder populations like the Ashkenazi-Jewish community, where unselected BRCA testing has shown to be feasible, reduce anxiety, and potentially save costs. However, the review underscores the need for further studies in diversepopulations to address specific cultural concerns and optimize counseling and education strategies. The implications of PBGT extend beyond individual health benefits, providing opportunities for family planning and cascade testing among relatives, thus amplifying its preventive impact. The article concludes by advocating for the integration of PBGT into healthcare systems to enhance early detection and precision prevention of women's cancers.

Item Type:	Article
Subjects:	R Medicine > RG Gynecology and obstetrics
Divisions:	Postgraduate > Master's of Management
Depositing User:	Journal Editor
Date Deposited:	16 Aug 2024 13:02
Last Modified:	16 Aug 2024 13:02
URI:	http://eprints.umsida.ac.id/id/eprint/14017

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